Only free curcumin crosses the blood-brain barrier, and CurcuMIND curcumin delivers a highly bioavailable free curcumin with superior clinical results.
90 veg caps
Key Benefits At A Glance:
- A powerful compound derived from turmeric
- Free from rapid breakdown by the body
- Remains in the bloodstream for up to 24 hours
The Benefits of Curcumin
Curcumin is a powerful anti-inflammatory derived from turmeric root. Due to its widespread mechanisms of action, curcumin has been studied for various conditions such as inflammatory disorders, especially those related to joint pain.
The Power of Curcumin + Vitamin D
AOR is the first company to offer curcumin with vitamin D in a single product. This combination brings together two highly beneficial nutrients whose synergistic effects are not only advantageous for the promotion of good health in general, but which also have amazing potential for the treatment of a variety of health conditions.
Inflammation: Regulated by the Immune System
Many conditions for which curcumin is helpful including chronic inflammatory disorders have also been shown to benefit from vitamin D supplementation. Recent research has brought the importance of vitamin D to the forefront by showcasing its role in preventing a wide variety of health issues. Deficiencies in this vitamin have now been linked to a dysfunctional immune system and severe inflammation. These connections make it an ideal partner for curcumin, which has been shown to provide support for these same issues.
Do Not Confuse Turmeric Root with Curcumin!
Turmeric root supplements absolutely do not offer the same benefits as those containing isolated curcumin. Curcumin is the most potent component of the turmeric root. Unfortunately, turmeric root contains less than 2% of curcumin making it ineffective for any health benefits. In addition, over 95% of all clinical studies have been conducted using isolated curcumin and NOT with the turmeric root. Even 750 mg of a 10:1 ratio extract of turmeric will deliver no more than 150 mg of the active curcumin. But given the poor bioavailability (the amount of the active compound that reaches the target site or site of action) of this compound, the amount you actually get is likely far less than that. Clinical studies suggest that the bioavailability is less than 5%, making even standard 95% curcumin formulations fairly ineffective. As for a significantly weakened turmeric root formula? That becomes essentially useless!
Longvida®, a highly bioavailable form of curcumin, is the result of testing over two hundred formulations and has taken more than ten years to develop. In a human bioavailability study involving patients, Longvida® curcumin was shown to be far more bioavailable than regular curcumin. This formulation was developed and patented by UCLA Medical School and is licensed exclusively to AOR.
Other benefits are:
Nine capsules provide 1000 IU of Vitamin D which works synergistically with curcumin
Gota and colleagues did a safety and bioavailability study on healthy volunteers versus patients. Subjects were given doses between 400 and 1,200 mg of curcumin in solid lipid particle form (equivalent to 3 to 9 capsules of CurcuMIND). All doses showed significant absorption into the bloodstream over 8 hours with no adverse events.
Longvida® Curcumin in Humans
A human trial on curcumin showed statistically significant effects on clinical endpoints in a healthy population. The fact that such a low dose (80 mg) was needed to achieve effects in only 30 days is an interesting and unique finding as well, and adds to the substantial amount of pharmacokinetic and pharmacodynamic data compiled on Longvida®. The results of the study suggest that curcumin can produce beneficial effects in people who are without immediate disease states. The study was conducted on 38 healthy middle aged people between the age of 40 and 60 who were either given a dose of 80 mg/day of Longvida® curcumin extract for four weeks or were a part of the 19 person placebo group. The study is particularly interesting because the relatively small dose of curcumin, from Longvida® which was used, exerted a variety of health promoting effects leading researchers to presume that a significant amount of the curcumin was absorbed, although not tested directly.
Blood sample readings collected from test subjects to assess nitric oxide and sICAM molecules were notably affected by the curcumin. Interestingly, other markers of inflammation and free radicals/toxic species that cause inflammation and damage to cells were also significantly lowered. Both direct and indirect antioxidant actions of curcumin were evident in the subjects; these findings are consistent with in vitro and animal studies used to measure increases in curcumin induced antioxidant enzyme activity.
New Technology – Better Products!
Numerous supplements on the market contain the curcumin extract of turmeric. However, many of these are poorly absorbed and offer little value in terms of therapeutic benefit due to their poor bioavailability. Over the last ten years a great deal of research has been done to develop formulations that improve the bioavailability of curcumin. The goal has been to deliver more of the active molecules to the body in a much lower daily dose in as few as one to three capsules per day. There have been a number of technologies developed, but the one that has provided the most compelling evidence is nano-technology.
Longvida® curcumin was introduced to Canada exclusively by AOR in 2011. CurcuMIND is clinically proven to deliver several health benefits as a result of its high bioavailability and has the following advantages:
Clinically tested with results published in 2010 in the prestigious Journal of Agricultural and Food Chemistry. In the study, patients experienced few to no adverse effects and good tolerability of the equivalent of up to 9 capsules of CurcuMIND
Higher bioavailability compared to regular curcumin
Patented by the University of California
Recent human study showing positive effects on markers of health with just 80 mg of Longvida® curcumin per day for 1 month
CurcuMIND™ consists of solid lipid particles (SLP) which are tiny particles that have a protected layer that provides a phenomenal increase in stability, potency and effectiveness. Unlike regular curcumin that is easily broken down by stomach acids, Curcumin Fast Relief particles are resistant to acid breakdown. Even more important is the fact that these tiny particles are absorbed very rapidly. This means that they deliver all of the health benefits of curcumin, including pain relief, reduced inflammation, antioxidant properties and other effects much faster than any other curcumin product. Try CurcuMIND™ today and start feeling the benefits of a real high-potency, high-bioavailability curcumin supplement.
|Serving Size: 3 capsules||Amount Per Serving|
|Longvida® Optimized Curcumin* (from Curcuma longa root 25-30:1)||400mg|
|Vitamin D3||333 IU/8.33mcg|
Non-Medicinal Ingredients: ascorbyl palmitate, microcrystalline cellulose, soy lecithin, stearic acid, maltodextrin, tapioca dextrin, silicon dioxide. Capsule: hypromellose.
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, soy, eggs, fish, shellfish or any animal byproduct
Suggested Dose And Usage:
Take up to 3 capsules three times daily, or as directed by a qualified health care practitioner.
Warnings And Contraindications:
Consult a health care practitioner prior to use if you are pregnant, taking antiplatelet medication or blood thinners, have gallstones or a bile duct obstruction, have stomach ulcers or excess stomach acid. Consult a health care practitioner if symptoms persist or worsen.
Pregnancy/Nursing: Consult a health care practitioner
Statements about these products and health conditions have not been evaluated by Health Canada or the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent disease. For the Complete disclosure statement click here.
Baum et al. Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease. Journal of Clinical Psychopharmacology. 2008; 28(1): 110-113.
Begum AN et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208
Fiala M, Mahanian M, Rosenthal M, Mizwicki MT, Tse E, Cho T, Sayre J, Weitzman R, Porter V. MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer’s disease by vitamin D and curcuminoids. J Alzheimers Dis. 2011;25(1):135-44.
Frautschy, SA. 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008.
Gota VS et al. Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers. J Agric Food Chem. 2010; 58(4): 2095-2099.
Hamaguchi T et al. REVIEW: Curcumin and Alzheimer’s Disease. CBS Neuroscience and Therapeutics. 2010; 16(5): 285-297.
Haussler MR et al. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutrition Reviews. 2008; 68: S98-S112.
Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwickie M, Cashman J, Fiala M. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2009;17(3):703-17.
Ray B, Lahiri DK. Neuroinflammation in Alzheimer’s disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009 Aug;9(4):434-44.