CurcuViva - AOR

Key Benefits At A Glance:

• Cutting edge technology for enhanced effectiveness
• Fast relief of joint pain and inflammation
• At least 100 times more bioavailable than standard curcumin extracts
• Each capsule is EQUIVALENT TO 8g of a standard curcumin extract

Product Description:

Curcumin – Superior Relief from Pain and Inflammation
Curcumin from turmeric root is well known for its anti-inflammatory and pain relieving properties, which are well supported by clinical studies. These studies have shown that curcumin is highly effective for improving joint mobility and for reducing stiffness, swelling and pain. Due to its widespread mechanisms of action, curcumin has been studied for conditions such as cancer, Alzheimer’s disease, irritable bowel disease (IBD), colitis, diabetes, rheumatoid arthritis, viral infections such as hepatitis, drug-resistant bacterial infections, healing of skin conditions, and more.

However, until recently, very high doses of curcumin (over 8g per day) have been required to achieve these results. Furthermore, many products on the market can be highly misleading, and may not be effective at all! Being aware of what is actually in each product and taking advantage of the latest advances in nutraceutical technology can help to ensure that you are getting the best possible curcumin supplement, and therefore the most effective relief from pain and inflammation.

Why is CurcuVIVA better?
CurcuVIVA is based on the latest in curcumin technology, and provides the most bioavailable curcumin extract on the market. This new technology uses tiny curcumin nano-particles encased in a lipid (fat soluble) coating. This patented Solid Lipid Particle TechnologyTM improves bioavailability by more than 100 times compared to ordinary curcumin! This means that each 80 mg capsule of CurcuVIVA is equivalent to 8 g or about 20 capsules of a 95% curcumin extract, and around 60 capsules of a 750 mg turmeric root extract! The result of all of this is a fast acting, highly effective curcumin supplement in a dose of just one capsule per day!

The Problems with Other Turmeric and Curcumin Products
It is essential to understand that turmeric root and curcumin are not the same thing! Curcumin is only a small component of turmeric root, but it is the component that is associated with health benefits. The vast majority of clinical studies have been conducted using curcumin, not turmeric root! As such, most turmeric formulas, which contain as little as 2% curcumin, are essentially useless!

Unfortunately, the problems do not stop there. Even if you are getting a high proportion of curcumin (like in a 95% curcumin extract) it is important to consider the bioavailability of the product. Curcumin on its own is absorbed very poorly by the body, meaning that it has extremely low bioavailability. Low bioavailability means low effectiveness. Studies suggest that you need to take more than 8g of a regular 95% curcumin extract before it becomes detectable in your blood! Taking this many capsules per day just to achieve an effective dose is highly inconvenient and costly!

Research
Curcumin is currently being heavily studied for use as an adjunct to conventional cancer treatments. Unfortunately, most of the studies have noted minimal results despite promising in vitro and animal studies. Researchers have recognized that the cause for the poor results is curcumin’s poor bioavailability.

Bioavailability
Gota and colleagues did a safety and bioavailability study on healthy volunteers and patients with non-responsive bone cancer. Subjects were given doses between 400 and 1,200 mg of curcumin in solid lipid particle form (equivalent to 3 to 9 capsules of Curcumin Active). All doses showed significant absorption into the bloodstream over 8 hours with no adverse events. This is especially significant since previous studies giving 8,000-12,000 mg of pure regular curcumin barely showed any blood levels or clinical improvements.  In addition, the 1,200 mg dose produced blood levels of curcumin necessary to reduce isoprostanes, TNF-α, and amyloid-β, which are markers for diseases like cancer and Alzheimer’s disease.

Amyloid-β Reductions
There is also significant interest in its ability to reduce amyloid-β plaque, which is thought to be a causative factor of Alzheimer’s disease. In vitro and animal studies have shown that curcumin can significantly reduce levels of amyloid-β and preserve Alzheimer model animal memory. Finally, a recent human study has shown that just 80 mg of curcumin can reduce amyloid-β in humans. The curcumin that was finally able to do so was Longvida® curcumin SLP, and in just one month.

Longvida® Curcumin in Humans
A human trial on curcumin showed statistically significant effects on clinical endpoints in a healthy population. The fact that such a low dose (80 mg) was needed to achieve effects in only 30 days is an interesting and unique finding as well, and adds to the substantial amount of pharmacokinetic and pharmacodynamic data compiled on Longvida®. The results of the study suggest that curcumin can produce beneficial effects in people who are without immediate disease states. The study was conducted on 38 healthy middle aged people between the age of 40 and 60 who were either given a dose of 80 mg/day of Longvida® curcumin extract for four weeks or were a part of the 19 person placebo group. The study is particularly interesting because the relatively small dose of curcumin, from Longvida® which was used, exerted a variety of health promoting effects leading researchers to presume that a significant amount of the curcumin was absorbed, although not tested directly.

Blood sample readings collected from test subjects to assess nitric oxide and sICAM molecules which are relevant to assessing cardiovascular risk and related to blood pressure and atherosclerosis, were notably affected by the curcumin. Both readings corresponded to a decreased risk of cardiovascular disease. The study also indicated that curcumin may have a positive effect on liver health maintenance as was noted from the reduction of indicators used to mark liver injury. Participants had lowered levels of triglycerides which relates to other research demonstrating that cholesterol could potentially be lowered in relatively healthy persons given higher dosages of the substance, thus benefiting those with or at risk of having cardiovascular disease.

Interestingly, other markers of inflammation and free radicals/toxic species that cause inflammation and damage to cells were also significantly lowered. Both direct and indirect antioxidant actions of curcumin were evident in the subjects; these findings are consistent with in vitro and animal studies used to measure increases in curcumin induced antioxidant enzyme activity.

Market Trends
Numerous supplements on the market contain the curcumin extract of turmeric or just straight turmeric extract. However, many of these are poorly absorbed and offer little value in terms of therapeutic benefit due to their poor bioavailability.

New Technology – Better Products!
Over the last ten years a great deal of research has been done to develop formulations that improve the bioavailability of curcumin. The goal has been to deliver more of the active molecules to the body in a much lower daily dose; as few as one to three capsules per day. There have been a number of technologies developed, but the one that has provided the most compelling evidence is nano-technology.

AOR Advantage: Longvida® curcumin was introduced to Canada exclusively by AOR in 2011. CurcuVIVA’s advanced technology allows it to be absorbed very rapidly by the body, meaning that it is an excellent choice for rapid pain relief. Furthermore, with an effective dose of just one capsule per day CurcuVIVA is more convenient and more economical than most other curcumin supplements out there!

AOR’s CurcuVIVA^TM is based on this proven technology and has the following advantages:

CurcuVIVA^TM consists of solid lipid particles (SLP) which are tiny nano-sized (1 billionth of a meter) particles that have a protected layer that provides a phenomenal increase in stability, potency and effectiveness. Unlike regular curcumin that is easily broken down by stomach acids, Curcumin Fast Relief particles are resistant to acid breakdown. Even more important is the fact that these tiny particles are absorbed very rapidly. This means that they deliver all of the health benefits of curcumin, including pain relief, reduced inflammation, antioxidant properties and other effects much faster than any other curcumin product.

Try CurcuVIVA^TM today and start feeling the benefits of a real high-potency, high-bioavailability curcumin supplement.

Supplement Facts:

Serving Size: 1 Capsule         

Turmeric Extract 25:1 (containing 80 mg Longvida® Optimized Curcumin)     348 mg

LONGVIDA® is a registered trademark of/ Verdure Sciences Inc. International patent pending. Non-medicinal ingredients: ascorbyl palmitate, soy lecithin, maltodextrin, microcrystalline cellulose, purified water, silicon dioxide, stearic acid. Capsule: hypromellose.
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, eggs, fish, shellfish, or any animal byproduct

Suggested Dose and Usage:

Take 1 capsule per day, or as directed by a qualified health care practitioner.   

Warnings And Contraindications:

Consult a health care practitioner prior to use if you have stomach ulcers, excess stomach acid, gallstones, or a bile duct obstruction. Consult a health care practitioner if symptoms persist or worsen.

Pregnancy/Nursing: Consult a health care practitioner prior to use

Additional Learning And Information:

Fast-Acting, High BioAvailability Curcumin (from AOR)

Statements about these products and health conditions have not been evaluated by Health Canada or the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent disease. For the Complete disclosure statement click here.

Research:

Begum et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208.

Dadhaniya P, Patel C, Muchhara J, Bhadja N, Mathuria N, Vachhani K, Soni MG. Chronic safety of Longvida. Food Chem Toxicol. 2011 May 6.

Disilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79.

Frautschy, SA. Bioavailability, brain concentrations, activity and dose-response of Longvida® SLCP. 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008.

Frautschy, SA et al. Omega 3 DHA and a bioavailable curcumin formulation synergize for Alzheimer prevention. 39th Annual Meeting of the Society of Neuroscience , Chicago, IL October 2009.

Frautschy, SA et al. Efficacy of Longvida® in relation to systemic availability in the brain. 39th Annual Meeting of the Society of Neuroscience , Chicago, IL October 2009.

Gota et al. afety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Ag Food Chem 2010 58(4): 2095-2099.

Ray B, Lahiri DK. Neuroinflammation in Alzheimer’s disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009 Aug;9(4):434-44.